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UGT1A1*28 Detection (Testing Service)

Relating to Drug: Irinotecan is a cancer therapy drug. UGT1A1 gene promoters usually have 5-8 TA repeat, most people with 6/6 TA repeat, few people are 6/7 or 7/7 TA repeat, 7 TA repeat genotypes were named for the UGT1A1*28.

RUO

In 2006, the U.S. FDA added UGT1A1*28 genotype information to the drug label for Irinotecan and to assess the potential value of genotyping of UGT1A1∗28 in patients before starting treatment with irinotecan to reduce the risk of severe toxicity.

Test Method

Product validation by sequencing method and specimen testing by HRM methodology.

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