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Genetic Testing for Common Medications in Children

Genetic testing for common medications in children

  • Child’s First Genetic Test
  • Lifetime Benefits
  • Precision medicine
  • Including medicine for common diseases in nine specialty
  • Eight categories、33 kinds of medication
  • Contains PharmiGENE’s proprietary drug-gene
    • 8 types of Antipyretic analgesics
    • 7 types of medicines for digestive system medication
    • 3 types of medication for respiratory
    • 1 type of infection medicine
    • 1 type of medication for ADHD
    • 6 types of medicines for Anti-epileptics
    • 7 kinds of medicines for Neurological
    • 1 type of  Metabolism medicine

Significance of Testing

Best way to protect children

  •  A single dosing error can lead to treatment failure or adverse drug reactions since Your child’s liver and kidneys are not fully developed.
  • Understanding the effects of metabolic reactions to genetic drugs can serve as a reference for physicians to help them select appropriate medications and doses to reduce the chance of adverse drug reactions in children.

What is pharmacogenetic testing

What is「pharmacogenetic」testing?

  • A gene is a “specification” of DNA sequences that carry genetic information passed down from parent to child. This specification helps us understand the risk of disease, unique physical condition, and more importantly, whether you are suitable for a drug, have allergies, need to adjust the dose, and other important information about taking medication.
  • Therefore, pharmacogenetic test results can provide physicians with more reference information to help them give patients the most appropriate medications and doses.
工作區域 1

Application

  • Newborn
  • Infant
  • Children
  • Adults

Process

1

Consultation Before Test

2

Sample Collection

3

panel-med

Genetic Test

4

panel-board

Report Produce

5

panel-doctor

Report Reveal PGx Information

Specimen type

Depending on requirements

Oral mucosa scraping

1

Gargle for 15 seconds

2

X1~3

Take out 1~3pcs of swaps

3

Up and down rotating slightly friction 10~15 times on the oral surface

4

Place the swab in the collection tube
Break the swab at the score line before tighten

Blood sampling

1

Clinical laboratory of the Medical institutions

2

Blood sampling 3ml
Fridge the blood collection tube(K2 ETDA) with 4°C temperature

Why PharmiGENE

Why PharmiGENE

  • We have licensed exclusive worldwide of relating Carbamazepine、Allopurinol, and Warfarin rights from Academia Sinica relating.
  • Based on CPIC, PharmGKB, and other databases, we update the latest report occasionally.
  • Combining the latest research data,  with clinical experience, with the most scientific, personalized, accurate information to tailor medication recommendations for individuals to provide physicians with individual genetic reports
  • As a pioneer of preventive medicine, as one of the few experts focusing on drug genetic testing, we will continue to practice research and application, keep close tabs on medication safety for everyone.

Reports

Output Report

Medication Assistant APP

IOS、Android
The database will updated irregularly
(This service is currently only available in Taiwan)

Physician interpretation and precision medicine

Inspection report

認識藥物不良反應及藥害 藥物不良反應 藥害 包括:藥物過敏與藥物副作用。(如下表) 根據藥害救濟基金會統計,申請藥害救濟案例中, 因嚴重藥物不良反應而致死的比例高達 30% ! 指因藥物不良反應致死亡、障礙或嚴重疾病。 ☉ 歷年藥害救濟受理案件申請類別統計圖(不含預防接種受害救濟案) 1. 過敏反應通常與接受藥物的劑量多寡無關, 與個人體質有關。 2. 當投予引起過敏的藥物,再次投予相同 物就會引發過敏反應。 3. 當對某種藥物產生過敏反應,也可能對 他化學結構式相似的藥物發生過敏反應。 4. 過敏反應常表現出:皮膚潮紅、 發癢、 起紅 、眼睛腫、心、呼吸困,嚴重者 出現休克與死。最典型的是出現在皮膚 的藥物,有疹塊且搔,嚴重時會造成 身皮膚或口腔黏膜等的潰爛如史帝文生- 強生症候群 (Stevens-Johnsonsyndrome)。 1. 為服用藥物後產生非期望的作用。 2. 藥品產生的副作用其發生率與嚴重度會因 ,通常與藥物劑量和代謝速率有 中藥量越高,所產生的副作用就越嚴重。 3. 部分藥品人體有時會適應某些副作,通 服用過幾次後, 會逐漸好轉。 4. 經長期臨床試,各種副作用及其發生率 逐漸明,仿單上會詳列其可能副作用以 ;此,國內外相關主管機關亦會定 針對上市後藥品不良反應通報提出更新建 與要求。 5. 副作用常表: 、嘔、腹、腸胃 、頭昏、 、睡眠障礙,依藥物的 同而異。 藥物過敏 藥物副作用 8% 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108.7 23% 7% 18% 12% 14% 16% 11% 10% 7% 4% 8% 6% 8% 7% 5% 27% 68% 11% 24% 65% 30% 63% 61% 31% 30% 64% 27% 65% 66% 30% 29% 64% 29% 61% 30% 59% 30% 54% 32% 54% 31% 58% 48% 34% 30% 63% 69% 死亡 類別 障礙 嚴重疾病 P5 認識藥物基因 當服用藥物誘發了非預期的免疫性抗拒 ,就稱之「藥物過敏。服用相同 藥物,不同的個體會產生不同的藥物 ,包含產生藥物預期療,無效或是 ,也是每個人擁有對藥物反應差異的 。而體,部分是因「基因」有所 同所造成的。 藥物過敏的檢測可透LTT (Lymphocyte Transformation Test)體外淋巴球藥物活 ,經由分離血中的周邊單核球細胞, 在體外以藥物刺激,偵測T細胞的活 ,當有明顯上升,代表血液中帶 藥物過敏的記憶T。除LTT驗, 另一種能採取的事前預防方法就是藥物 敏基因檢測。 在臨床上證實與藥物過敏高度相關的基因, HLA-B*5801、HLA-B*1502、 HLA-B*5701、HLA-B*1301,都可以 過預防性的藥物基因檢查來避免因用藥 能產生的嚴重過敏反應。 本檢測報告針對抗癲癇藥檢測 HLA-B*1502新陳代謝系統用藥 HLA-B*5801,其檢測結果以 / 陽性來表。有充分的研究結果 示, HLA-B*1502, HLA-B*5801 ,使用抗癲癇Carbamzepine、 Oxcarbazepine和Phenytoin或新陳 謝系統用Allopurinol,易產生嚴 的藥物不良反應史帝文生- 強生症候 (SJS)/ 毒性表皮壞死溶解(TEN)致死 30%–40%此, HLA-B*1502, HLA-B*5801檢測結果為陽,則不建 使 Carbamazepine、Oxcarbazepine Phenytoin,Allopurinol。 藥物過敏基因 P7